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Nolvadex has a peripheral effect – it blocks estrogen receptors, thereby preventing further tumor development, but does not directly affect estrogen levels in the blood. Therefore, Nolvadex is usually used together with a drug that affects the central mechanisms of regulation of sex hormone levels, i.e., the hypothalamic-pituitary axis. This effect is exerted by the luteinizing hormone-releasing factor analogue (RF LH) goserelin, which is produced under the trade name ZOLADEX by AstraZeneca.
Hormone therapy for cancer
Hormone therapy for cancer has achieved considerable success in its half-century of development. After the introduction of non-steroidal anti-estrogens into clinical practice in the early 70s (Izuo M., 1992), the most famous of which is tamoxifen, progress in the treatment of breast cancer (BC) was outlined. This drug, manufactured by AstraZeneca under the trade name Nolvadex, is now widely available worldwide for the treatment of breast cancer. Nolvadex is the “gold standard” in the treatment of women with this pathology.
Nolvadex has a peripheral effect – it blocks estrogen receptors, thus preventing further tumor development, but does not directly affect estrogen levels in the blood. Therefore, Nolvadex is usually used together with a drug that affects the central mechanisms of regulation of sex hormone levels, i.e., the hypothalamic-pituitary axis. This effect is exerted by the luteinizing hormone-releasing factor analogue (RF LH) goserelin, which is produced under the trade name ZOLADEX by AstraZeneca. Experience of clinical use of the drug confirms its antitumor activity against hormone-dependent tumors. ZOLADEX promotes the reduction of sex hormone levels in blood in men and women, which provides its therapeutic effect in this pathology (Nicholson R., 1991).
The effectiveness of ZOLADEX in the treatment of tumors that do not depend on sex hormone levels is due to the fact that receptors to RF LH were found in breast and prostate tumors, through which the direct antitumor effect of ZOLADEX is realized (Segal-Abramson T. et al., 19). Currently, the drug is used in the treatment of BC, prostate cancer (PC), uterine myoma, endometriosis, it is effective in the treatment of patients with dysfunctional uterine bleeding and polycystic ovarian syndrome.
Scientific studies have also confirmed the effectiveness of ZOLADEX in the treatment of ovarian cancer, pancreatic cancer, benign prostatic hyperplasia, etc. ZOLADEX can be used to protect ovarian and testicular function during cytostatic chemotherapy. ZOLADEX has been used extensively for the treatment of breast cancer and cancer cell carcinoma.
Study of the drug, Nolvadex – tamoxifen before and after on female
The use of ZOLADEXA is as effective as castration, but without the negative effects associated with surgery. The results of clinical studies show that the use of ZOLADEXA promotes a complete or partial remission in one out of three women under the age of 55 years old with recurrent or metastatic breast cancer. The median duration of remission was 36-64 weeks and the median survival was 141-148 weeks. In addition, stabilization of the process was observed in every fourth patient. The results of the studies carried out in England and Germany show that objective remission developed in 36.4% of the patients, and subjective effect (such as a decrease in the severity of pain) was observed in 68.3% of patients.
In women with breast cancer, the use of combined hormone therapy with ZOLADEX is promising. Similar to the treatment of BC, “complete estrogen blockade”, which can be achieved by combining RF analogue of LH and anti-estrogen drugs, increases the effectiveness of BC treatment. The leader among anti-estrogens, certainly, is Nolvadex (tamoxifen), developed by specialists of Zeneca company more than 20 years ago. The results of a study involving 115 patients with bone metastases have confirmed that the combination of ZOLADEX and tamoxifen has undeniable advantages in terms of response rate, time to progression, and survival rate. In 85 patients with inoperable breast cancer the combination of ZOLADEX and tamoxifen was significantly more effective.
The combination of ZOLADEX with aromatase inhibitors, which includes the new drug ARIMIDEX (anastrozole) for AstraZeneca, is effective. This estrogen blockade is preferable for postmenopausal women in whom almost all estrogens are produced through androgen aromatization. The results of clinical studies have confirmed the efficacy of this combination in the progression of the tumor process against the background of ZOLADEX treatment.
Effects of Nolvadex – Tamoxifen before and after use
For breast cancer patients, the effects of Nolvadex are very simple. By blocking the estrogen hormone compound, the cancer cannot feed on the hormone it needs to survive. Although it is effective, it is not always the only compound used, or even the first one used. Often aromatase inhibitors (AIs) are used early on because they have the ability to lower serum estrogen levels. Over time, there will be a transition from AIs to SERMs, similar to Nolvadex. As a preventive measure, those with a strong family history of breast cancer can prevent it by using Nolvadex early.
For anabolic steroid users, the main effect of Nolvadex on the course is to prevent gynecomastia. Nolvadex does not appear to have a strong effect on preventing the other major estrogenic effect associated with water retention, but it can often be controlled in other ways. As for protection against gynecomastia, this may be enough for many men, and it should be your first choice if it can do the job. If not, you will need an AI, such as Arimidex (Anastrozole) or Femara (Letrozole). However, AIs can have a negative effect on cholesterol. AIs alone do not seem to have a strong negative effect, but when combined with aromatizing steroids, the effect seems to be annoying. Cholesterol can be controlled with an AI, but if it can do the job, a SERM such as Nolvadex should be your first choice. As an added bonus.
The final effect of Nolvadex represents the most value to the anabolic steroid consumer. The use of anabolic steroids suppresses the natural production of testosterone. The rate of suppression will depend on the steroids used, but in most cases, it will be significant. Once the use of anabolic steroids comes to an end, provided that the man has not suffered from a previous low testosterone condition and has not damaged his hypothalamic-pituitary-ovarian axis (HPTA) due to improper practice, natural testosterone production will begin again.
This natural production will begin on its own, however, there is a problem. Once you come out of the cycle, your natural testosterone levels will be extremely low, and although production will resume, they will remain at low levels for a very long time. It will take the body months and months to fully restore your previous high natural testosterone levels. In fact, it could take up to a year or more, depending on the severity of the cycle and the overall predisposition of the man. This means that a man will be in a state of low testosterone for quite some time, which can be accompanied by many unpleasant symptoms. with low testosterone.
Nolvadex is a medication that is prescribed to treat breast cancer in women. It can also be used to prevent breast cancer in women who are at high risk for the disease. Tamoxifen, the active ingredient in Nolvadex, is a hormone therapy drug that blocks the effects of estrogen in the body. This can help to slow or stop the growth of breast cancer cells. Nolvadex is also effective in treating cancer that has spread to other parts of the body.
Nolvadex – tamoxifen is a Product used by athletes to prevent gynecomastia, or the development of female breast tissue in males. It is also sometimes used to increase the testosterone level. Nolvadex – tamoxifen comes as a tablet that is usually taken once a day with water. The dosage and how often it is taken depends on your medical condition and response to treatment. There are many benefits to using Nolvadex – tamoxifen before and after your Product cycle. For one, it can help you maintain your muscle mass while on steroids. It can also help you reduce the amount of fat that you accumulate, and it can minimize the chance of developing gynecomastia. Additionally, it can improve your cholesterol levels and increase your libido.